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235 results

A study to evaluate the efficacy and safety of gliclazide MR in patients with type 2 diabetes inadequately controlled with dapagliflozin with or without metformin

Servier Protocol Code
S005201-175
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Completed

Exploratory Bioavailability of Three Formulations of Gliclazide MR Tablets 120 mg (I.R.I.S.) in Healthy Volunteers Under Fed Conditions (High Fat High Calorie Meal and Standard Meal)

Servier Protocol Code
S005190-213
EU Trial (CTIS) Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Comparative pharmacokinetic study of three prolonged release formulations and one immediate release formulation of S221237 after single oral administration in fed conditions. An open-label, randomized, four-period, four-sequence, one-way cross-over, single center, phase I study in Caucasian healthy male participants.

Servier Protocol Code
S221237-176
EU Trial (CTIS) Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Exploratory bioavailability of two formulations of gliclazide MR tablets 120 mg (I.R.I.S.) in healthy volunteers under fed and fasting conditions

Servier Protocol Code
S005190-170
EU Trial (CTIS) Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Study assessing the glucose-lowering efficacy and safety of luseogliflozin on top of metformin in Caucasian patients with type 2 diabetes mellitus

Servier Protocol Code
CL3-LUSEO-001
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Evaluation of the clinical efficacy and safety of perindopril 10 mg/indapamide 2.5 mg/amlodipine 5 or 10 mg/bisoprolol 5 mg in single-pill combination after 8 weeks of treatment versus the free combination of perindopril 10 mg, indapamide 2.5 mg and amlodipine 5 or 10 mg in patients with uncontrolled essential hypertension. An international, multicentre, randomised, double-blind, 16-week study.

Servier Protocol Code
CL3-05179-002
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

A Multi-center, Open-label, Single-arm Phase 2/3 Trial Evaluating the Safety and Pharmacokinetics of Calaspargase Pegol for Treatment of Adults Aged 22 To >65 Years with Newly-diagnosed Philadelphia-negative ALL

Servier Protocol Code
CL2-95015-001
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Active, not recruiting

A Multicentre, Randomized, Double-blind, Placebo-controlled Dose-finding Study of S62798 in Patients with Intermediate-High Risk Acute Pulmonary Embolism on heparin

Servier Protocol Code
CL2-62798-010
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Phase I / II, Open Label, Dose Escalation Part (Phase I) Followed by Noncomparative Expansion Part (Phase II), Multi-centre Study, Evaluating Safety, Pharmacokinetics and Efficacy of S65487, a Bcl2 Inhibitor Combined With Azacitidine in Adult Patients With Previously Untreated Acute Myeloid Leukemia Not Eligible for Intensive Treatment

Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

A Phase I/II, open label, non-randomized study to evaluate safety, tolerability, pharmacokinetics and clinical activity of S64315 in patients with locally advanced or metastatic breast cancer in combination with various standard treatments including hormonal and cytotoxic agents

Servier Protocol Code
CL1-64315-003
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Efficacy and safety of 3 doses of S201086/GLPG1972 administered orally once daily in patients with knee osteoarthritis. A 52-week international, multi-regional, multi-center, randomized, double-blind, placebo-controlled, dose-ranging study.

Servier Protocol Code
CL2-201086-002
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Efficacy of ivabradine in combination with beta-blockers vs up-titration of beta-blockers in daily practice

Servier Protocol Code
Control-2
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

A clinical study to test the safety and the efficacy of a single-pill combination of 2 antihypertensive and 1 lipid-lowering drug in patients already well treated with the concomitant administration of the same three drugs on separate tablets

Servier Protocol Code
CL3-05153-008
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Clinical non-inferiority study between Micronized purified flavonoid fraction 1000 mg, one chewable tablet per day and Micronized Purified Flavonoid Fraction 500 mg, 2 tablets daily after eight weeks of treatment in patients suffering from symptomatic Chronic Venous Disease (CVD). International, multicenter, double-blind, randomized, parallel group study

Servier Protocol Code
CL3-05682-109
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Phase I/II study of S49076, a multi-target inhibitor of c-MET, AXL, FGFR in combination with bevacizumab in patients with recurrent glioblastoma multiforme

Servier Protocol Code
CL1-49076-002
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

INES – Phase Ib dose allocation study of oral administration of lucitanib given in combination with fulvestrant in patients with oestrogen receptor-positive and FGFR1-amplified or non-amplified metastatic breast cancer.

Servier Protocol Code
CL1-80881-002
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Prospective, Multicenter, Open-label Phase IV trial of Trifluridine/Tipiracil to Evaluate the Health-related Quality of Life in Patients with Metastatic Colorectal Cancer

Servier Protocol Code
IC4-95005-183-DEU
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Assessment of the acceptability of a sublingual formulation of piribedil (S90049), 10 to 30 mg on request (maximum 5 times a day) on the top of L-dopa and a dopamine agonist in advanced Parkinson Disease patients with motor fluctuations: a 4-week open label pilot study

Servier Protocol Code
SC3-90049-001
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Effect of 3 doses (20, 40 and 60 mg) of a sublingual formulation of piribedil (S 90049) in combination with levodopa on end-of-dose fluctuations in advanced Parkinson’s disease patients after a 14-day treatment-period (one administration t.i.d.). A randomised, double-blind study consisting of 3 cross-over: 40 mg versus placebo, 20 mg versus 60 mg and 40 mg versus 20 mg. – PARKOPI

Servier Protocol Code
SC2-90049-003
EudraCT Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

A study to assess the release profiles from fixed combination tablets (gliclazide MR/metformin)

Servier Protocol Code
PKH-05720-001
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4

Phase 3 Study of Vorasidenib (S095032/AG-881) in Asian Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 orIDH2 Mutation

Servier Protocol Code
CL3-95032-016
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

A Phase 2 Study of Ivosidenib in Previously Treated Japanese Subjects With Nonresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Servier Protocol Code
CL2-95031-008
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Active, not recruiting

Non-drug Treatment Study in Parkinson's Disease Patients and Healthy Volunteers to Collect Biological Samples in Order to Assess ex Vivo the Activity of Candidate Therapies and Develop Novel Analytical Methods for Biomarkers (IRIS-CLE-LRRK2)

Servier Protocol Code
CLE-221237-001
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Completed

Evaluation of the Clinical Efficacy and Safety of Amlodipine 5mg/ Bisoprolol Fumarate 5mg /Perindopril Arginine 5mg Fixed-dose Combination in Capsule and Free Monotherapy at the Same Dose in Patients With Uncontrolled Essential Hypertension.

Servier Protocol Code
CL3-05166-003
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Completed

An Experimental Medicine Clinical Study to Compare Peripheral Immune System From Subjects Without Cancer Diagnosis and Patients With Solid Tumours. (IMMUNOPBMC)

Servier Protocol Code
2021-A01796-35
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Terminated

A Study of an IDH1m Inhibitor in Participants With IDH1-Mutated Malignancies and Hepatic or Renal Impairment

Servier Protocol Code
S095031-218
Clinicaltrials.gov Identifier
EU Trial (CTIS) Number
2024-517923-38-00
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Not yet recruiting

A Study to Evaluate S227928 as a Single Agent and in Combination With Venetoclax in Patients With R/R AML, MDS/AML, or CMML

Servier Protocol Code
S227928-180
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

S095035 as a Single Agent and in Combination in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of MTAP

Servier Protocol Code
CL1-95035-001
Clinicaltrials.gov Identifier
EU Trial (CTIS) Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

Phase 1b/2 Platform Study of Select Immunotherapy Combinations in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)

Servier Protocol Code
SPLFIO-174
Clinicaltrials.gov Identifier
EU Trial (CTIS) Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen (CHONQUER)

Servier Protocol Code
CL3-95031-007
Clinicaltrials.gov Identifier
EU Trial (CTIS) Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

A Study to Evaluate the Safety and the Activity of S095029 as Part of Combination Therapy in Advanced Gastroesophageal Junction/Gastric Cancers.

Servier Protocol Code
CL1-95029-002
Clinicaltrials.gov Identifier
EudraCT Number
2023-507995-33
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

Ivosidenib, Nivolumab, and Ipilimumab Combination in Previously Treated Subjects With Nonresectable or Metastatic IDH1 Mutant Cholangiocarcinoma

Servier Protocol Code
CL1-95031-006
Clinicaltrials.gov Identifier
EU Trial (CTIS) Number
2023-503236-41-00
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Completed

A Phase 1, Open-Label Study to Evaluate the Effect of a Low-Fat Meal and Multiple Doses of Ciprofloxacin on the Pharmacokinetics of Vorasidenib in Healthy Subjects

Servier Protocol Code
PKH-95032-009
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Completed

A Study of PRS-344/S095012 (PD-L1x4-1BB Bispecific Antibody-Anticalin Fusion) in Patients With Solid Tumors

Servier Protocol Code
CL1-95012-001
Clinicaltrials.gov Identifier
EudraCT Number
2019-003456-36
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Completed

Ivosidenib Plus Durvalumab and Gemcitabine/Cisplatin as First-Line Therapy in Participants With Locally Advanced or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Servier Protocol Code
S095031-210
Clinicaltrials.gov Identifier
EU Trial (CTIS) Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma

Servier Protocol Code
S095032-211
Clinicaltrials.gov Identifier
EU Trial (CTIS) Number
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation (PyramIDH)

Servier Protocol Code
S095031-178
Clinicaltrials.gov Identifier
EudraCT Number
2023-510155-37
EU Trial (CTIS) Number
2023-510155-37-00
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

Phase 2 Study of Irinotecan Liposome Injection, Oxaliplatin, 5-fluorouracil/Levoleucovorin in Japanese Participants Not Previously Treated for Metastatic Adenocarcinoma of the Pancreas

Servier Protocol Code
S095013-169
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Active, not recruiting

Efficacy and Safety of Perindopril 5 mg / Indapamide 1.25 mg / Amlodipine 5 mg Fixed Combination in Hypertension

Servier Protocol Code
CL3-6593-018
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Completed

A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers

Servier Protocol Code
BDTX-4933-101
Clinicaltrials.gov Identifier
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Trial Details
Recruiting

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