An Experimental Medicine Clinical Study to Compare Peripheral Immune System From Subjects Without Cancer Diagnosis and Patients With Solid Tumours. (IMMUNOPBMC)
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Study description
The immune system (made of organs, certain blood cells, proteins and other substances) is designed to defend the body against foreign or dangerous invaders including abnormal cells. In some cases, abnormal cells can escape the control of the immune system. This may lead to the development of cancer. At this stage, the immune system may be prevented from functioning properly by the tumour itself to promote the growth of the cancer. It is therefore important to understand what goes wrong with the immune system to discover new treatments for cancer.
This study was done to gain knowledge on components of the immune system from persons without cancer diagnosis and persons with cancer. The participants did not receive any treatment as part of this study. The main aim of the study was to find out if the levels of certain immune system components (called immune profile) are similar between participants without cancer and those with advanced solid tumour cancer. Solid tumour cancers are abnormal growths of cells in organ(s) of the body such as the lung, liver, or colon. In advanced stages of disease, solid tumours may spread in the body.
English (USA)
Français (France)- blood samples
- 2021-A01796-35
Eligibility Criteria
Eligible age for the study
Sexes
Male/FemaleAccepts Healthy Volunteers
YesTo take part, participants had to:
- Be 45 to 70 years of age.
- Belong to one of the 4 groups:
- For group 1
- Have a specific type of lung cancer called non-small cell lung cancer.
- For group 2
- Have colorectal cancer. Colorectal cancer is a cancer that starts in the large bowel and involves the rectum (the lowest part of the gut).
- For group 3
- Have cancer of the pancreas (the organ lying behind the lower part of the stomach that produces digestive substances and certain chemical substances called hormones).
- For group 6
- Be an individual without cancer diagnosis.
Due to difficulties to find new participants, the 2 optional groups planned (group 4 and group 5) were not opened.
Participants could not take part in the study if:
- They had received anticancer treatment with drugs or radiation within 14 days before starting the study.
- They had received drugs that affect how the immune system works (called immunomodulators) within 6 months before starting the study.